The Catholic Monarchs chose the city of Granada as their burial site by a royal decree dated September 13, 1504. The Royal Chapel of Granada, built over the former terrace of the Great Mosque, ranks with other important Granadan buildings such as the Lonja and the Catedral e Iglesia del Sagrario. In it are buried the Catholic Monarchs, their daughter Joanna of Castile and Philip I of Castile. Construction of the Chapel started in 1505, directed by its designer, Enrique Egas. Built in several stages, the continuing evolution of its design joined Gothic construction and decoration with Renaissance ideals, as seen in the tombs and the 17th and 18th century Granadan art in the Chapel of Santa Cruz. Over the years the church acquired a treasury of works of art, liturgical objects and relics.
The Royal Chapel was declared a Historic Artistic Monument on May 19, 1884, taking consideration of B.I.C. (Bien de Interés Cultural) in the current legislation of the Spanish Historical Heritage (Law 16/1985 of 25 June). The most important parts of the chapel are its main retable, grid and vault. In the Sacristy-Museum is the legacy of the Catholic Monarchs. Its art gallery is highlighted by works of the Flemish, Italian and Spanish schools.